Mfg Part Number
bAb0164
Vector Labs bAb0164 Anti-EGFRvIII [L8A4], Mouse IgG2a mCD3e KIH bispecific, Fc Silent™, kappa (50 μg)
Quick Overview
Pep 3-KLH (Pep 3 is a 14-amino acid peptide corresponding to the predicted amino acid sequence at the fusion junction and KLH stands for keyhole limpet hemocyanin) at da 40 and 103, HC2 20 d2 cells at day 1, 25, 74, 87. And fusion with the nonimmunoglobulin-secreting Kearney variant of P3X63/Ag8.653.
$531.70
Order will ship within 1-3 business days
| Product Class: | Purified |
|---|---|
| Clone ID: | L8A4 |
| Heavy Chain Modification: | Fc Silent™ |
| Synonyms: | Epidermal Growth Factor Receptor variant III |
| Amount: | 50 μg |
| Application Codes Clone: | IF; IHC; Biacore; WB; ELISA; FC |
| Shipping Temperature: | Wet Ice |
| Origin Pub PMID: | 9352535 |
| Buffer Composition: | PBS with 0.02% Proclin 300. |
| Original Format: | IgG1 |
| Storage Temperature: | Store at 4⁰C for up to 3 months. For longer storage, aliquot and store at -20⁰C. |
| Chimeric Use Statement: | This is a bispecific, knob-into-hole heterodimerized antibody, with one arm directed against human EGFRvIII (Fab) and one arm directed against mouse CD3e (scFv). |
| Specificity Statement: | Binds EGFRvIII, a mutated form of EGFR, plays a prominent role in tumorigenesis. |
| Application Notes: | This antibody can be used to detect EGFRvIII, a mutated EGFR variant, in immunohistochemical staining, Western Blot, ELISA and flow-cytometry. Chou et al (2016, PMID: 27825958) used this antibody to detect EGFRvIII in acetone and PFA fixed sections by fluorescent immunohistochemistry. |
| Brand | Vector Labs |
|---|---|
| UNSPSC | 12161500 |