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Mfg Part Number

bAb0505-BS

Vector Labs bAb0505-BS Anti-NKG2D [CX-5], Mouse IgG2a mCD3e KIH bispecific, Fc Silent™, lambda (1 mg)

VECTOR LABS

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Quick Overview

The original rat IgG1 version of this antibody was raised by immunizing rats against mouse KLRK1.

$4,197.70

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Description

Product Class: Purified
Clone ID: CX-5
Heavy Chain Modification: Fc Silent™
Synonyms: CD314; KLRK1; NKG2-D type II integral membrane protein; Killer cell lectin-like receptor subfamily K member 1; NK cell receptor D; NKG2-D-activating NK receptor; CX5
Amount: 1 mg
Application Codes Clone: FC, blocking, neutralizing
Shipping Temperature: Wet Ice
Buffer Composition: PBS only.
Original Format: IgG1
Storage Temperature: Store at 4⁰C for up to 3 months. Note, this antibody is provided without added preservatives, it is therefore recommed this antibody be handled under sterile conditions. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement: This is a bispecific, knob-into-hole heterodimerized antibody, with one arm directed against mouse NKG2D (Fab) and one arm directed against mouse CD3e (scFv).
Specificity Statement: This antibody recognizes mouse NKG2D, a lectin-like molecule expressed on both human and mouse NK cells. Mouse NKG2D binds to retinoic acid-inducible RAE-1 alpha, beta, gamma, delta, epsilon and the minor histocompatibility molecule H60 and has the ability to costimulate multiple NK activation receptors, through the DAP12/DAP10 adaptor molecules. NKG2D is expressed by all spleen and liver NK cells, NK1.1 thymocytes, in vitro activated LAK cells, and a subset of splenic NKT cells.
Application Notes: It has been shown that CX5 is a non-depleting antibody, which blocks binding of NKG2D to its ligands and mediates internalization of the receptor. This antibody has been widely used to block NKG2D (Wang et al., 2018; pmid: 29447423; Yang et al., 2017; pmid: 28455530) as well as to detect NKG2D-posotive cells via flow cytometry (Hosomi et al., 2017; pmid: 28747426).

Product Class:	Purified
Clone ID:	CX-5
Heavy Chain Modification:	Fc Silent™
Synonyms:	CD314; KLRK1; NKG2-D type II integral membrane protein; Killer cell lectin-like receptor subfamily K member 1; NK cell receptor D; NKG2-D-activating NK receptor; CX5
Amount:	1 mg
Application Codes Clone:	FC, blocking, neutralizing
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS only.
Original Format:	IgG1
Storage Temperature:	Store at 4⁰C for up to 3 months. Note, this antibody is provided without added preservatives, it is therefore recommed this antibody be handled under sterile conditions. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement:	This is a bispecific, knob-into-hole heterodimerized antibody, with one arm directed against mouse NKG2D (Fab) and one arm directed against mouse CD3e (scFv).
Specificity Statement:	This antibody recognizes mouse NKG2D, a lectin-like molecule expressed on both human and mouse NK cells. Mouse NKG2D binds to retinoic acid-inducible RAE-1 alpha, beta, gamma, delta, epsilon and the minor histocompatibility molecule H60 and has the ability to costimulate multiple NK activation receptors, through the DAP12/DAP10 adaptor molecules. NKG2D is expressed by all spleen and liver NK cells, NK1.1 thymocytes, in vitro activated LAK cells, and a subset of splenic NKT cells.
Application Notes:	It has been shown that CX5 is a non-depleting antibody, which blocks binding of NKG2D to its ligands and mediates internalization of the receptor. This antibody has been widely used to block NKG2D (Wang et al., 2018; pmid: 29447423; Yang et al., 2017; pmid: 28455530) as well as to detect NKG2D-posotive cells via flow cytometry (Hosomi et al., 2017; pmid: 28747426).

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

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