Vector Labs bAb0615-BS Anti-PD-L1 [10F.9G2], Mouse IgG2a mCD3e KIH bispecific, Fc Silent™, kappa (1 mg) Centrifuge Bundle Savings at Sycamore Life Sciences

Description

Product Class: Purified
Clone ID: 10F.9G2
Heavy Chain Modification: Fc Silent™
Synonyms: CD274; PDL1; PD L1; Programmed cell death 1 ligand 1; PDCD1 ligand 1; Programmed death ligand 1; B7 homolog 1; B7-H1; 10F9G2; 10F 9G2
Amount: 1 mg
Application Codes Clone: ELISA; FC; IHC; blocking
Shipping Temperature: Wet Ice
Buffer Composition: PBS only.
Original Format: IgG2b
Storage Temperature: Store at 4⁰C for up to 3 months. Note, this antibody is provided without added preservatives, it is therefore recommed this antibody be handled under sterile conditions. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement: This is a bispecific, knob-into-hole heterodimerized antibody, with one arm directed against mouse PD-L1 (Fab) and one arm directed against mouse CD3e (scFv).
Specificity Statement: This antibody is specific for murine PD-L1.
Application Notes: The specificity of this antibody has been confirmed in ELISA analysis (Eppihimer et al, 2002). This antibody reacts specifically with mPD-L1-transfected cells in flow cytometry, and has been used to assess microvascular endothelial cells PD-L1 expression (Eppihimer et al, 2002). When administered to mice, a radiolabelled version of this antibody has been used to quantify PD-L1 expression in vivo, by measuring antibody accumulation in different tissues (Eppihimer et al, 2002). This antibody has also been used in immunohistochemical analysis of PD-L1 expression in frozen tissue sections of murine brain (Eppihimer et al, 2002) and murine hearts (Rodig et al, 2003). This antibody has been shown to block the binding of PD-L1 to both PD-1 and B7-1 (Paterson et al, 2011). This antibody precipitates diabetes in NOD mice and in adoptive transfer models of CD4+ and CD8+ T cell-driven diabetes, and accelerates diabetes in recipients of T cells from diabetic and prediabetic mice (Paterson et al, 2011).

Product Class:	Purified
Clone ID:	10F.9G2
Heavy Chain Modification:	Fc Silent™
Synonyms:	CD274; PDL1; PD L1; Programmed cell death 1 ligand 1; PDCD1 ligand 1; Programmed death ligand 1; B7 homolog 1; B7-H1; 10F9G2; 10F 9G2
Amount:	1 mg
Application Codes Clone:	ELISA; FC; IHC; blocking
Shipping Temperature:	Wet Ice
Buffer Composition:	PBS only.
Original Format:	IgG2b
Storage Temperature:	Store at 4⁰C for up to 3 months. Note, this antibody is provided without added preservatives, it is therefore recommed this antibody be handled under sterile conditions. For longer storage, aliquot and store at -20⁰C.
Chimeric Use Statement:	This is a bispecific, knob-into-hole heterodimerized antibody, with one arm directed against mouse PD-L1 (Fab) and one arm directed against mouse CD3e (scFv).
Specificity Statement:	This antibody is specific for murine PD-L1.
Application Notes:	The specificity of this antibody has been confirmed in ELISA analysis (Eppihimer et al, 2002). This antibody reacts specifically with mPD-L1-transfected cells in flow cytometry, and has been used to assess microvascular endothelial cells PD-L1 expression (Eppihimer et al, 2002). When administered to mice, a radiolabelled version of this antibody has been used to quantify PD-L1 expression in vivo, by measuring antibody accumulation in different tissues (Eppihimer et al, 2002). This antibody has also been used in immunohistochemical analysis of PD-L1 expression in frozen tissue sections of murine brain (Eppihimer et al, 2002) and murine hearts (Rodig et al, 2003). This antibody has been shown to block the binding of PD-L1 to both PD-1 and B7-1 (Paterson et al, 2011). This antibody precipitates diabetes in NOD mice and in adoptive transfer models of CD4+ and CD8+ T cell-driven diabetes, and accelerates diabetes in recipients of T cells from diabetic and prediabetic mice (Paterson et al, 2011).

Specifications

More Information
Brand	Vector Labs
UNSPSC	12161500

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